Pair Name	Gedunin, Epalrestat
Disease Info	[ICD-11: 2B66.Z]	Oral cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in the G1/S phase
Gene Regulation	Down-regulation	Expression	AKT1	hsa207
	Down-regulation	Expression	AR	hsa367
	Down-regulation	Expression	CHUK	hsa1147
	Down-regulation	Expression	MAPK1	hsa5594
	Down-regulation	Expression	NFKB1	hsa4790
	Down-regulation	Expression	ROS1	hsa6098
In Vitro Model	SCC-131	Rat squamous cell carcinoma	Rattus norvegicus (Rat)	CVCL_6726
Result	Our results provide compelling evidence that the combination of gedunin and epalrestat modulates expression of key oncogenic signalling kinases and transcription factors primarily by influencing phosphorylation and subcellular localisation. AR inhibitors such as gedunin and epalrestat are novel candidate agents for cancer prevention and therapy.